GRISEOFULVIN TABLETS 100 Tablets - ANTIFUNGAL 500 mg - Buy Antibiotics Tretinoin Medicine Drugs Skincare Online Tretinoin Hydroquinone USA & UK World
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all antifungal antifungals griseofulvin griseofulvin 500mg Other Skincare price_42.99$
GRISEOFULVIN TABLETS 100 Tablets - ANTIFUNGAL 500 mg

GRISEOFULVIN TABLETS 100 Tablets - ANTIFUNGAL 500 mg

all antifungal antifungals griseofulvin griseofulvin 500mg Other Skincare price_42.99$
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Product Description


          



Indications
Dermatophytosis.
Dosage
Adult : PO 0.5-1 g/day in single or divided doses. Treatment duration: 2-8 wk (hair and skin infections); up to 6 mth (fingernail infections); ≥12 mth (toenail infections).
Dosage Details
Oral
Dermatophytosis
Adult: 0.5-1 g daily in single or divided doses. Treatment duration: 2-8 wk (hair and skin infections); up to 6 mth (fingernail infections); ≥12 mth (toenail infections).
Child: 10 mg/kg daily in divided doses.
Administration
Should be taken with food. Take immediately after meals.
Contraindications
Hypersensitivity to griseofulvin. SLE and porphyria. Severe liver disease, hepatocellular failure. Pregnancy.
Special Precautions
Not intended for prophylaxis of fungal infections. Men should not father children w/in 6 mth of treatment. Lactation.
Adverse Drug Reactions
Skin rashes, urticaria, GI disturbances, dry mouth, taste alteration, headache, angioedema, leucopenia and other blood dyscrasias, proteinuria, oral candidiasis, peripheral neuropathy, photosensitisation, dizziness, confusion, depression, impaired coordination, insomnia, fatigue, exacerbation of SLE.
Potentially Fatal: Severe skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme), hepatotoxicity.
Pregnancy Category (US FDA)
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
Patient Counselling
Avoid exposure to intense natural or artificial sunlight. May impair ability to drive or operate machinery.
Monitoring Parameters
Monitor hepatic, renal and haematopoietic functions (esp w/ long term use) periodically.
Drug Interactions
May reduce the efficacy of OCs, phenylbutazone, sedative and hypnotic drugs, and coumarin anticoagulants. Decreased GI absorption w/ barbiturates. 
Food Interaction
Increased absorption w/ food, esp high-fat meals. May enhance the effect of alcohol.
Lab Interference
False-positive urinary vanillylmandelic acid (VMA) levels.
Mechanism of Action
Description: Griseofulvin inhibits fungal cell division at metaphase by disrupting the cell's mitotic spindle structure. It binds to human keratin, making it resistant to fungal infections; may also interfere w/ deoxyribonucleic acid (DNA) production.
Pharmacokinetics: 
Absorption: Variably and incompletely absorbed from the GI tract; may be increased by decreasing particle size and admin w/ fatty meals. Time to peak plasma concentrations: W/in 4 hr.
Distribution: Deposited in keratin precursor cells and concentrated in stratum corneum of the skin and in the nail and hair. Plasma protein-binding: Approx 84% (mainly albumin).
Metabolism: Hepatically metabolised to 6-demethylgriseofulvin and its glucuronide conjugates.
Excretion: Via urine (mainly as metabolites, <1% as unchanged drug); faeces (large amount as unchanged drug); some in sweat. Elimination half-life: 9-24 hr.
Storage
Store between 15-30°C.
MIMS Class
Antifungals
ATC Classification
D01BA01 - griseofulvin ; Belongs to the class of antifungals for systemic use. 
D01AA08 - griseofulvin ; Belongs to the class of antibiotics. Used in the topical treatment of fungal infection.