Palenox Adapalene 0.1 %gel
Indications
Acne vulgaris.
Dosage
Adult : Topical As 0.1% soln/cream/gel or 0.3% gel: Apply once daily at night.
Dosage Details
Topical/Cutaneous
Acne vulgaris
Adult: As 0.1% soln/cream/gel or 0.3% gel:
Apply thinly onto affected areas once daily at night after cleansing.
Special Precautions
Not intended for application to broken, sunburnt or eczematous skin.
Pregnancy and lactation.
Adverse Drug Reactions
Mild skin irritation, scaling, erythema, dryness, stinging and burning, pruritus, rash, eczema, acne flare, dermatitis, skin discolouration, sunburn.
Pregnancy Category (US FDA)
ROUTE(S) : Topical
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Patient Counselling
Avoid exposure to excessive sunlight and UV irradiation.
Drug Interactions
Additive irritant effects w/ peeling agents, astringents, abrasive cleaners, strong drying agents or irritant products (e.g. aromatic and alcoholic agents).
Mechanism of Action
Description: Adapalene normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. It binds to specific retinoic acid nuclear receptors.
Onset: 8-12 wk.
Pharmacokinetics:
Absorption: Minimal.
Excretion: Via bile. Terminal elimination half-life: 7-51 hr (gel).
Storage
Store between 20-25°C. Protect from light.
